Am J Blood Res 2013;3(4):286-289
Case Report
Chronic myelogenous leukemia after postoperative adjuvant S-1 therapy for
rectal cancer: a case report
Masahiro Manabe, Takafumi Nishii, Junya Okita, Johji Nagasaki, Naonori Harada, Yasutaka Aoyama, Takeo Kumura,
Tadanobu Ohta, Yoshio Furukawa, Kazuhiro Takeuchi, Atsuko Mugitani
Department of Hematology, Seichokai Fuchu Hospital, 1–10–17 Hiko–cho, Izumi, Osaka 594–0076, Japan; Department of
Surgery, Seichokai Fuchu Hospital, 1–10–17 Hiko–cho, Izumi, Osaka 594–0076, Japan
Received November 28, 2013; Accepted December 12, 2013; Epub December 18, 2013; Published December 30, 2013
Abstract: We report a case in which chronic myelogenous leukemia (CML) developed after postoperative adjuvant S-1 therapy
for rectal cancer. A 56-year-old man was diagnosed with rectal adenocarcinoma, which was treated with abdominoperineal
resection followed by a year of adjuvant S-1 therapy. At 39 postoperative months, he was diagnosed with CML. Although it
remains unclear that CML that develops after treatment involving cytotoxic agents is treatment-related, clinicians should be
aware of the possibility of CML developing after S-1 therapy. (AJBR1311001).
Keywords: Chronic myelogenous leukemia, rectal cancer, fluoropyrimidine, S-1
Address correspondence to: Masahiro Manabe, Department of Hematology, Seichokai Fuchu Hospital, 1–10–17 Hiko–cho,
Izumi, Osaka 594–0076, Japan. Tel: 81–725–43–1234; Fax: 81–725–41–0900; E-mail: m1153564@med.osaka-cu.ac.jp
Case Report
Chronic myelogenous leukemia after postoperative adjuvant S-1 therapy for
rectal cancer: a case report
Masahiro Manabe, Takafumi Nishii, Junya Okita, Johji Nagasaki, Naonori Harada, Yasutaka Aoyama, Takeo Kumura,
Tadanobu Ohta, Yoshio Furukawa, Kazuhiro Takeuchi, Atsuko Mugitani
Department of Hematology, Seichokai Fuchu Hospital, 1–10–17 Hiko–cho, Izumi, Osaka 594–0076, Japan; Department of
Surgery, Seichokai Fuchu Hospital, 1–10–17 Hiko–cho, Izumi, Osaka 594–0076, Japan
Received November 28, 2013; Accepted December 12, 2013; Epub December 18, 2013; Published December 30, 2013
Abstract: We report a case in which chronic myelogenous leukemia (CML) developed after postoperative adjuvant S-1 therapy
for rectal cancer. A 56-year-old man was diagnosed with rectal adenocarcinoma, which was treated with abdominoperineal
resection followed by a year of adjuvant S-1 therapy. At 39 postoperative months, he was diagnosed with CML. Although it
remains unclear that CML that develops after treatment involving cytotoxic agents is treatment-related, clinicians should be
aware of the possibility of CML developing after S-1 therapy. (AJBR1311001).
Keywords: Chronic myelogenous leukemia, rectal cancer, fluoropyrimidine, S-1
Address correspondence to: Masahiro Manabe, Department of Hematology, Seichokai Fuchu Hospital, 1–10–17 Hiko–cho,
Izumi, Osaka 594–0076, Japan. Tel: 81–725–43–1234; Fax: 81–725–41–0900; E-mail: m1153564@med.osaka-cu.ac.jp
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