Am J Blood Res 2013;3(2):186-190
Case Report
A rare der(Y)t(Y;1)(q12;q12) in a patient with post-polycythemic myelofibrosis:
a case report
Masahiro Manabe, Osami Takeda, Junya Okita, Teruhito Takakuwa, Naonori Harada, Hirofumi Nakano, Shuichiro Okamoto,
Yasutaka Aoyama, Takeo Kumura, Tadanobu Ohta, Yoshio Furukawa, Atsuko Mugitani
Department of Hematology, Seichokai Fuchu Hospital, 1–10–17 Hiko–cho, Izumi, Osaka 594–0076, Japan; Department of
Gastroenterology, Seichokai Fuchu Hospital, 1–10–17 Hiko–cho, Izumi, Osaka 594–0076, Japan
Received March 5, 2013; Accepted March 29, 2013; Epub May 5, 2013; Published May 15, 2013
Abstract: We describe a case of post-polycythemic myelofibrosis harboring der(Y)t(Y;1)(q12;q12). The patient was a 69-year-
old man and was initially diagnosed with polycythemia vera. During the clinical course of his condition, the polycythemia
developed into myelofibrosis. Chromosome analysis detected der(Y)t(Y;1)(q12;q12). We discuss the association between der
(Y)t(Y;1)(q11~12;q12~21) and tumorigenesis along with a review of literature. (AJBR1303001).
Keywords: Post-polycythemic myelofibrosis, der(Y)t(Y;1)(q12;q12), chromosomal abnormality
Address correspondence to: Dr. Masahiro Manabe, Department of Hematology, Seichokai Fuchu Hospital, 1–10–17 Hiko–
cho, Izumi, Osaka 594–0076, Japan. Phone: 81–725–43–1234; Fax: 81–725–41–0900; E-mail: m1153564@med.osaka-cu.ac.
jp
Case Report
A rare der(Y)t(Y;1)(q12;q12) in a patient with post-polycythemic myelofibrosis:
a case report
Masahiro Manabe, Osami Takeda, Junya Okita, Teruhito Takakuwa, Naonori Harada, Hirofumi Nakano, Shuichiro Okamoto,
Yasutaka Aoyama, Takeo Kumura, Tadanobu Ohta, Yoshio Furukawa, Atsuko Mugitani
Department of Hematology, Seichokai Fuchu Hospital, 1–10–17 Hiko–cho, Izumi, Osaka 594–0076, Japan; Department of
Gastroenterology, Seichokai Fuchu Hospital, 1–10–17 Hiko–cho, Izumi, Osaka 594–0076, Japan
Received March 5, 2013; Accepted March 29, 2013; Epub May 5, 2013; Published May 15, 2013
Abstract: We describe a case of post-polycythemic myelofibrosis harboring der(Y)t(Y;1)(q12;q12). The patient was a 69-year-
old man and was initially diagnosed with polycythemia vera. During the clinical course of his condition, the polycythemia
developed into myelofibrosis. Chromosome analysis detected der(Y)t(Y;1)(q12;q12). We discuss the association between der
(Y)t(Y;1)(q11~12;q12~21) and tumorigenesis along with a review of literature. (AJBR1303001).
Keywords: Post-polycythemic myelofibrosis, der(Y)t(Y;1)(q12;q12), chromosomal abnormality
Address correspondence to: Dr. Masahiro Manabe, Department of Hematology, Seichokai Fuchu Hospital, 1–10–17 Hiko–
cho, Izumi, Osaka 594–0076, Japan. Phone: 81–725–43–1234; Fax: 81–725–41–0900; E-mail: m1153564@med.osaka-cu.ac.
jp
| AJBR Copyright © 2011-present, All rights reserved. Published by e-Century Publishing Corporation, Madison, WI 53711, USA |
 |  |  |  |  |  |  |