Am J Blood Res 2013;3(1):52-57
Review Article
Regulatory T-cells in chronic lymphocytic leukemia:
actor or innocent bystander?
Giovanni D’Arena, Vittorio Simeon, Fiorella D’Auria, Teodora Statuto, Paola Di Sanzo, Laura De Martino, Aurelio Marandino,
Michele Sangiorgio, Pellegrino Musto, Vincenzo De Feo
Onco-Hematology Department, IRCCS Centro di Riferimento Oncologico della Basilicata, Rionero in Vulture, Italy; Laboratory
of Preclinical and Translational Research, IRCCS Centro di Riferimento Oncologico della Basilicata, Rionero in Vulture, Italy;
Laboratory of Clinical Re-search and Advanced Diagnostics, IRCCS Centro di Riferimento Oncologico della Basilicata,
Rionero in Vulture, Italy; Department of Pharmacy, University of Salerno, Salerno, Italy
Received November 28, 2012; Accepted December 29, 2012; Epub January 17, 2013; Published January 25, 2013
Abstract: Regulatory T (Treg) cells are now under extensive investigation in chronic lymphocytic leukemia (CLL). This small
subset of T-cells has been, in fact, considered to be involved in the pathogenesis and progression of CLL. However, whether
Treg dysregulation in CLL plays a key role or it rather represents a simple epiphenomenon is still matter of debate. In the
former case, Treg cells could be appealing for targeting therapies. Finally, Treg cells have also been proposed as a
prognostic indicator of the disease clinical course. (AJBR1211003).
Keywords: Tregs, chronic lymphocytic leukemia, prognosis
Address all correspondence to:
Dr. Giovanni D’Arena
Onco-Hematology Department
IRCCS Centro di Riferimento Oncologico della Basilicata
Via Padre Pio n. 1, 85028 Rionero in Vulture (PZ), Italy.
Phone: +39 0972 726521; Fax: +39 0972 726217
E-mail: giovannidarena@libero.it
Review Article
Regulatory T-cells in chronic lymphocytic leukemia:
actor or innocent bystander?
Giovanni D’Arena, Vittorio Simeon, Fiorella D’Auria, Teodora Statuto, Paola Di Sanzo, Laura De Martino, Aurelio Marandino,
Michele Sangiorgio, Pellegrino Musto, Vincenzo De Feo
Onco-Hematology Department, IRCCS Centro di Riferimento Oncologico della Basilicata, Rionero in Vulture, Italy; Laboratory
of Preclinical and Translational Research, IRCCS Centro di Riferimento Oncologico della Basilicata, Rionero in Vulture, Italy;
Laboratory of Clinical Re-search and Advanced Diagnostics, IRCCS Centro di Riferimento Oncologico della Basilicata,
Rionero in Vulture, Italy; Department of Pharmacy, University of Salerno, Salerno, Italy
Received November 28, 2012; Accepted December 29, 2012; Epub January 17, 2013; Published January 25, 2013
Abstract: Regulatory T (Treg) cells are now under extensive investigation in chronic lymphocytic leukemia (CLL). This small
subset of T-cells has been, in fact, considered to be involved in the pathogenesis and progression of CLL. However, whether
Treg dysregulation in CLL plays a key role or it rather represents a simple epiphenomenon is still matter of debate. In the
former case, Treg cells could be appealing for targeting therapies. Finally, Treg cells have also been proposed as a
prognostic indicator of the disease clinical course. (AJBR1211003).
Keywords: Tregs, chronic lymphocytic leukemia, prognosis
Address all correspondence to:
Dr. Giovanni D’Arena
Onco-Hematology Department
IRCCS Centro di Riferimento Oncologico della Basilicata
Via Padre Pio n. 1, 85028 Rionero in Vulture (PZ), Italy.
Phone: +39 0972 726521; Fax: +39 0972 726217
E-mail: giovannidarena@libero.it
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