Am J Blood Res 2012;2(3):194-200
Original Article
Gastrointestinal malignant lymphoma: a pathologic study of 37 cases in a
single Japanese institution
Tadashi Terada
Department of Pathology, Shizuoka City Shimizu Hospital, Shizuoka, Japan
Received September 20, 2012; accepted October 14, 2012; Epub October 20, 2012; Published October 3o, 2012
Abstract: The author reviewed pathologic features of 37 cases of malignant lymphoma in the gastrointestinal organs in the
last 10 years in our pathology laboratory. The current WHO classification was adopted. The 37 cases consisted of 20 males
and 17 female, and the age ranged from 46 to 89 years with a median of 69 years. Of the 37 cases, 25 cases (68%) were
gastric lymphomas, 6 cases (16%) were small intestinal lymphomas, and 6 cases (16%) were colon lymphomas. Of the 37
cases, 35 cases (95%) were B-cell neoplasms and 2 cases (5%) were T-cell neoplasms. In the 25 gastric lymphomas (male:
female=14:11, age range 46-84 years, median 70 years) 11 cases were diffuse large B-cell lymphomas, and 14 cases were
extranodal marginal zone B-cell lymphomas (MALT lymphomas). The clinical endoscopic diagnosis was gastritis in 3, gastric
ulcer in 3, gastric carcinoma in 7, carcinoid in 1, submucosal tumor in 1, malignant lymphoma in 2, and suspected MALT
lymphoma in 8. In the 6 small intestinal lymphomas (male:female=2:4, age range 49-89 years, median 70 years), all cases
were located in the ileum. Of the 6 cases, 4 were diffuse large B-cell lymphoma and 2 were peripheral T-cell lymphoma. One
case showed multiple lymphomas, and one case was associated with rectal adenocarcinoma and one case with gastric
MALT lymphoma. The clinical diagnosis was adenocarcinoma in 2, suspected lymphoma in 2, and ileal tumor in 2. In the 6
colon lymphomas (male:female=4:2, age range 69-86 years, median 74 years), 5 cases were diffuse large B-cell lymphomas
and one case was follicular lymphoma. Clinical endoscopic diagnosis was GIST in 1, colon carcinoma in 4, and colon polyp
in 1. Cases of Hodgkin’s disease, mantle cell lymphoma, Burkitt lymphoma were not recognized in the present series. In
summary, the author reported pathologic features of 37 cases of gastrointestinal malignant lymphoma in our laboratory in the
last 10 years. (AJBR1209004).
Keywords: Malignant lymphoma, gastrointestinal organs
Address all correspondence to:
Dr. Tadashi Terada, Department of Pathology, Shizuoka City Shimizu Hospital, Miyakami 1231 Shimizu-Ku, Shizuoka 424-
8636, Japan. Tel: 81-54-336-1111; Fax: 81-54-336-1315; E-mail: piyo0111jp@yahoo.co.jp
Original Article
Gastrointestinal malignant lymphoma: a pathologic study of 37 cases in a
single Japanese institution
Tadashi Terada
Department of Pathology, Shizuoka City Shimizu Hospital, Shizuoka, Japan
Received September 20, 2012; accepted October 14, 2012; Epub October 20, 2012; Published October 3o, 2012
Abstract: The author reviewed pathologic features of 37 cases of malignant lymphoma in the gastrointestinal organs in the
last 10 years in our pathology laboratory. The current WHO classification was adopted. The 37 cases consisted of 20 males
and 17 female, and the age ranged from 46 to 89 years with a median of 69 years. Of the 37 cases, 25 cases (68%) were
gastric lymphomas, 6 cases (16%) were small intestinal lymphomas, and 6 cases (16%) were colon lymphomas. Of the 37
cases, 35 cases (95%) were B-cell neoplasms and 2 cases (5%) were T-cell neoplasms. In the 25 gastric lymphomas (male:
female=14:11, age range 46-84 years, median 70 years) 11 cases were diffuse large B-cell lymphomas, and 14 cases were
extranodal marginal zone B-cell lymphomas (MALT lymphomas). The clinical endoscopic diagnosis was gastritis in 3, gastric
ulcer in 3, gastric carcinoma in 7, carcinoid in 1, submucosal tumor in 1, malignant lymphoma in 2, and suspected MALT
lymphoma in 8. In the 6 small intestinal lymphomas (male:female=2:4, age range 49-89 years, median 70 years), all cases
were located in the ileum. Of the 6 cases, 4 were diffuse large B-cell lymphoma and 2 were peripheral T-cell lymphoma. One
case showed multiple lymphomas, and one case was associated with rectal adenocarcinoma and one case with gastric
MALT lymphoma. The clinical diagnosis was adenocarcinoma in 2, suspected lymphoma in 2, and ileal tumor in 2. In the 6
colon lymphomas (male:female=4:2, age range 69-86 years, median 74 years), 5 cases were diffuse large B-cell lymphomas
and one case was follicular lymphoma. Clinical endoscopic diagnosis was GIST in 1, colon carcinoma in 4, and colon polyp
in 1. Cases of Hodgkin’s disease, mantle cell lymphoma, Burkitt lymphoma were not recognized in the present series. In
summary, the author reported pathologic features of 37 cases of gastrointestinal malignant lymphoma in our laboratory in the
last 10 years. (AJBR1209004).
Keywords: Malignant lymphoma, gastrointestinal organs
Address all correspondence to:
Dr. Tadashi Terada, Department of Pathology, Shizuoka City Shimizu Hospital, Miyakami 1231 Shimizu-Ku, Shizuoka 424-
8636, Japan. Tel: 81-54-336-1111; Fax: 81-54-336-1315; E-mail: piyo0111jp@yahoo.co.jp
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