Am J Blood Res 2012;2(1):1-8
Review Article
Vav1 in hematologic neoplasms, a mini review
Matthew J Oberley, Dengshun Wang, David T Yang
Department of Pathology and Laboratory Medicine, University of Wisconsin School of Medicine and Public Health, Madison,
WI, USA.
Received December 9, 2011; accepted December 29, 2011; Epub January 1, 2012; published January 15, 2012
Abstract: The Vav family of proteins is guanine nucleotide exchange factors which have been shown to be deregulated in
several forms of human cancer. There are three members of the Vav family that have been identified which are part of the Dbl
domain superfamily and have specificity towards Rho/Rac GTPases. The Vav family plays an important role in normal
hematologic system development and homeostasis, and Vav1 is largely restricted to the hematologic system. While Vav1 was
originally identified as a proto-oncogene, several recent studies have shown that Vav family deletion leads to the development
of T-cell malignancies in mice. In addition, Vav1 has been shown to play a role in the ATRA-mediated differentiation of
promyelocytic leukemia cells. In this concise review, the gene structure and normal function of Vav1, as well as a possible role
for Vav1 in the development of hematologic and other malignancies is reviewed. (AJBR11120001).
Keywords: Vav1, guanine nucleotide exchange factor, lymphoma, leukemia
Full Text PDF
Address all correspondence to:
David T. Yang, MD
Department of Pathology and Laboratory Medicine
University of Wisconsin School of Medicine and Public Health
Madison, WI, USA.
E-mail: dtyang@wisc.edu
Review Article
Vav1 in hematologic neoplasms, a mini review
Matthew J Oberley, Dengshun Wang, David T Yang
Department of Pathology and Laboratory Medicine, University of Wisconsin School of Medicine and Public Health, Madison,
WI, USA.
Received December 9, 2011; accepted December 29, 2011; Epub January 1, 2012; published January 15, 2012
Abstract: The Vav family of proteins is guanine nucleotide exchange factors which have been shown to be deregulated in
several forms of human cancer. There are three members of the Vav family that have been identified which are part of the Dbl
domain superfamily and have specificity towards Rho/Rac GTPases. The Vav family plays an important role in normal
hematologic system development and homeostasis, and Vav1 is largely restricted to the hematologic system. While Vav1 was
originally identified as a proto-oncogene, several recent studies have shown that Vav family deletion leads to the development
of T-cell malignancies in mice. In addition, Vav1 has been shown to play a role in the ATRA-mediated differentiation of
promyelocytic leukemia cells. In this concise review, the gene structure and normal function of Vav1, as well as a possible role
for Vav1 in the development of hematologic and other malignancies is reviewed. (AJBR11120001).
Keywords: Vav1, guanine nucleotide exchange factor, lymphoma, leukemia
Full Text PDF
Address all correspondence to:
David T. Yang, MD
Department of Pathology and Laboratory Medicine
University of Wisconsin School of Medicine and Public Health
Madison, WI, USA.
E-mail: dtyang@wisc.edu
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