Am J Blood Res 2012;2(1):57-65
Review Article
The role of transcription factors in the guidance of granulopoiesis
Katja Fiedler, Cornelia Brunner
Institute of Physiological Chemistry, University Ulm, Germany
Received October 31, 2011; accepted November 17, 2011; Epub December 15, 2011; Published January 15, 2012
Abstract: In recent years, the prospective isolation of hematopoietic stem and progenitor cells has identified the hierarchical
structure of hematopoietic development and lineage-commitment. Moreover, these isolated cell populations allowed the
elucitation of the molecular mechansims associated with lineage choice and revealed the indispensable functions of
transcription factors as lineage determinants. This review summarizes current concepts regarding adult murine
granulopoiesis to illustrate the importance of the transcription factors C/EBP, PU.1 and GATA-2 for the development of
neutrophil, eosinophil and basophil granulocytes. (AJBR1110006).
Keywords: granulopoiesis, transcription factors, C/EBP-alpha
Full Text PDF
Address all correspondence to:
Cornelia Brunner, PhD
Institute of Physiological Chemistry
Ulm University
Albert-Einstein-Allee 11
D-89081 Ulm, Germany
Phone: 0049-731-500-33846
Fax: 0049-731-500-22892
Review Article
The role of transcription factors in the guidance of granulopoiesis
Katja Fiedler, Cornelia Brunner
Institute of Physiological Chemistry, University Ulm, Germany
Received October 31, 2011; accepted November 17, 2011; Epub December 15, 2011; Published January 15, 2012
Abstract: In recent years, the prospective isolation of hematopoietic stem and progenitor cells has identified the hierarchical
structure of hematopoietic development and lineage-commitment. Moreover, these isolated cell populations allowed the
elucitation of the molecular mechansims associated with lineage choice and revealed the indispensable functions of
transcription factors as lineage determinants. This review summarizes current concepts regarding adult murine
granulopoiesis to illustrate the importance of the transcription factors C/EBP, PU.1 and GATA-2 for the development of
neutrophil, eosinophil and basophil granulocytes. (AJBR1110006).
Keywords: granulopoiesis, transcription factors, C/EBP-alpha
Full Text PDF
Address all correspondence to:
Cornelia Brunner, PhD
Institute of Physiological Chemistry
Ulm University
Albert-Einstein-Allee 11
D-89081 Ulm, Germany
Phone: 0049-731-500-33846
Fax: 0049-731-500-22892
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