Am J Blood Res 2011;1(2):130-134
Review Article
Grb2-associated binding (Gab) proteins in hematopoietic and immune cell
biology
Tamisha Y. Vaughan, Sheetal Verma, Kevin D. Bunting
Department of Pediatrics, Aflac Cancer Center and Blood Disorders Service, Emory University, School of Medicine, Atlanta, GA,
USA.
Received June 30, 2011; accepted July 25, 2011; Epub August 8, 2011; published September 30, 2011
Abstract: Grb2-associated binding (Gab) scaffolding/adapter proteins are a family of three members including mammalian
Gab1, Gab2, and Gab3 that are highly conserved. Since the discovery of these proteins, there has been an extensive amount
of work done to better understand Gab functional roles in multiple signaling pathways, typically acting as a downstream
effectors of receptor-tyrosine kinase (RTK)-triggered signal transduction. In addition to their participation in hematopoiesis,
Gabs play important roles in regulation of immune response and in also in cancer cell signaling. Gabs may play complex
roles and thus a complete understanding of their interactions and how they modulate hematopoietic and immune cell biology
remains to be determined. This review will cover the most recent findings including the involvement of Gabs in disease
development and signaling which will be important for design of future therapeutic interventions. (AJBR1106003).
Keywords: Adapter protein, cytokine signaling, Grb2-associated binding protein, Gab, receptor tyrosine kinase, cancer
signaling
Full Text PDF
Address all correspondence to:
Kevin D. Bunting, PhD
Department of Pediatrics
Division of Hem/Onc/BMT &
Aflac Cancer Center and Blood Disorders Service
Emory University School of Medicine
2015 Uppergate Dr. NE, ECC #444
Atlanta, GA 30322
Tel: 404-778-4039
Email: Kevin.bunting@emory.edu
Review Article
Grb2-associated binding (Gab) proteins in hematopoietic and immune cell
biology
Tamisha Y. Vaughan, Sheetal Verma, Kevin D. Bunting
Department of Pediatrics, Aflac Cancer Center and Blood Disorders Service, Emory University, School of Medicine, Atlanta, GA,
USA.
Received June 30, 2011; accepted July 25, 2011; Epub August 8, 2011; published September 30, 2011
Abstract: Grb2-associated binding (Gab) scaffolding/adapter proteins are a family of three members including mammalian
Gab1, Gab2, and Gab3 that are highly conserved. Since the discovery of these proteins, there has been an extensive amount
of work done to better understand Gab functional roles in multiple signaling pathways, typically acting as a downstream
effectors of receptor-tyrosine kinase (RTK)-triggered signal transduction. In addition to their participation in hematopoiesis,
Gabs play important roles in regulation of immune response and in also in cancer cell signaling. Gabs may play complex
roles and thus a complete understanding of their interactions and how they modulate hematopoietic and immune cell biology
remains to be determined. This review will cover the most recent findings including the involvement of Gabs in disease
development and signaling which will be important for design of future therapeutic interventions. (AJBR1106003).
Keywords: Adapter protein, cytokine signaling, Grb2-associated binding protein, Gab, receptor tyrosine kinase, cancer
signaling
Full Text PDF
Address all correspondence to:
Kevin D. Bunting, PhD
Department of Pediatrics
Division of Hem/Onc/BMT &
Aflac Cancer Center and Blood Disorders Service
Emory University School of Medicine
2015 Uppergate Dr. NE, ECC #444
Atlanta, GA 30322
Tel: 404-778-4039
Email: Kevin.bunting@emory.edu
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