Am J Blood Res 2011;1(1):98-105
Original Article
Infectious complications in cord blood and T-cell depleted haploidentical stem
cell transplantation
Victor E. Mulanovich, Ying Jiang, Marcos de Lima, Elizabeth J. Shpall, Richard E. Champlin, Stefan O. Ciurea
Department of Infectious Diseases; Department of Stem Cell Transplantation and Cellular Therapy, The University of Texas
MD Anderson Cancer Center, Houston, TX, USA.
Received May 23, 2011; accepted June 5, 2011; Epub June 7, 2011; published June 15, 2011
Abstract: Infections due to post transplant immune deficiency is a major problem following allogeneic stem cell
transplantation, particularly in patients receiving cord blood or T-cell depleted haploidentical transplants. We evaluated the
incidence and type of infectious complications that occurred in these two types of transplant for 65 patients, 37 cord blood and
28 haploidentical, who received the same conditioning regimen: fludarabine, melphalan and thiotepa. While incidence of
infections appeared similar in both types of transplant, viral infections were more frequent than bacterial or fungal infections
and were the most common cause of death in both groups. Patients in the haploidentical group were 1.7 times (95% CI: 1.1 to
2.5) more likely to have a viral infection (p=0.013). Bacterial, fungal and CMV infections still quite frequent but contributed less
to mortality. Pneumonia was the most common clinical syndrome and the number one cause of death in both groups. Both
pneumonia and bacteremia occurred within the first 100 days in the majority of HSCT patients while CBT patients had a
bimodal distribution, with more than one third of episodes after 6 months post transplant. (AJBR1105007).
Keywords: Infectious complications, cord blood transplantation, T-cell depleted haploidentical stem cell transplantation
Full Text PDF
Address all correspondence to:
Stefan O. Ciurea, MD
Department of Stem Cell Transplantation and Cellular Therapy
1515 Holcombe Blvd., Unit 423
Houston, TX 77030
E-mail: sociurea@mdanderson.org
Original Article
Infectious complications in cord blood and T-cell depleted haploidentical stem
cell transplantation
Victor E. Mulanovich, Ying Jiang, Marcos de Lima, Elizabeth J. Shpall, Richard E. Champlin, Stefan O. Ciurea
Department of Infectious Diseases; Department of Stem Cell Transplantation and Cellular Therapy, The University of Texas
MD Anderson Cancer Center, Houston, TX, USA.
Received May 23, 2011; accepted June 5, 2011; Epub June 7, 2011; published June 15, 2011
Abstract: Infections due to post transplant immune deficiency is a major problem following allogeneic stem cell
transplantation, particularly in patients receiving cord blood or T-cell depleted haploidentical transplants. We evaluated the
incidence and type of infectious complications that occurred in these two types of transplant for 65 patients, 37 cord blood and
28 haploidentical, who received the same conditioning regimen: fludarabine, melphalan and thiotepa. While incidence of
infections appeared similar in both types of transplant, viral infections were more frequent than bacterial or fungal infections
and were the most common cause of death in both groups. Patients in the haploidentical group were 1.7 times (95% CI: 1.1 to
2.5) more likely to have a viral infection (p=0.013). Bacterial, fungal and CMV infections still quite frequent but contributed less
to mortality. Pneumonia was the most common clinical syndrome and the number one cause of death in both groups. Both
pneumonia and bacteremia occurred within the first 100 days in the majority of HSCT patients while CBT patients had a
bimodal distribution, with more than one third of episodes after 6 months post transplant. (AJBR1105007).
Keywords: Infectious complications, cord blood transplantation, T-cell depleted haploidentical stem cell transplantation
Full Text PDF
Address all correspondence to:
Stefan O. Ciurea, MD
Department of Stem Cell Transplantation and Cellular Therapy
1515 Holcombe Blvd., Unit 423
Houston, TX 77030
E-mail: sociurea@mdanderson.org
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