Am J Blood Res 2011;1(1):65-75
Review Article
Mouse models as tools to understand and study BCR-ABL1 disease
Steffen Koschmieder, Mirle Schemionek
Medizinische Klinik A, Universitätsklinikum Münster, Münster, Germany
Received May 16, 2011; accepted June 3, 2011; Epub June 7, 2011; published June 15, 2011
Abstract: Mouse models of human malignancy have greatly enhanced our understanding of dis-ease pathophysiology and
have led to novel therapeutic approaches, some with extraor-dinary success, one such example being inhibition of the
BCR-ABL1 oncogene in chronic myeloid leukemia (CML). Here, we review aspects of the biology of CML that have been
uncovered at least in part through the generation and analysis of retroviral and trans-genic mouse models of BCR-ABL1
disease. It can be expected that these models will also serve as important tools in the future, especially in the rational design
of strategies to eradicate leukemic stem cells and potentially cure CML as well as other cancers. (AJBR1105005).
Keywords: BCR-ABL1, mouse models, retroviral, transgenic. leukemic stem cells, hematopoietic stem cells
Full Text PDF
Address all correspondence to:
Steffen Koschmieder, MD
Medizinische Klinik A
Universitätsklinikum Münster
48149 Münster, Germany
Phone +49-251-8352721, Fax +49-251-8352673.
E-mail: Steffen.Koschmieder@ukmuenster.de
Review Article
Mouse models as tools to understand and study BCR-ABL1 disease
Steffen Koschmieder, Mirle Schemionek
Medizinische Klinik A, Universitätsklinikum Münster, Münster, Germany
Received May 16, 2011; accepted June 3, 2011; Epub June 7, 2011; published June 15, 2011
Abstract: Mouse models of human malignancy have greatly enhanced our understanding of dis-ease pathophysiology and
have led to novel therapeutic approaches, some with extraor-dinary success, one such example being inhibition of the
BCR-ABL1 oncogene in chronic myeloid leukemia (CML). Here, we review aspects of the biology of CML that have been
uncovered at least in part through the generation and analysis of retroviral and trans-genic mouse models of BCR-ABL1
disease. It can be expected that these models will also serve as important tools in the future, especially in the rational design
of strategies to eradicate leukemic stem cells and potentially cure CML as well as other cancers. (AJBR1105005).
Keywords: BCR-ABL1, mouse models, retroviral, transgenic. leukemic stem cells, hematopoietic stem cells
Full Text PDF
Address all correspondence to:
Steffen Koschmieder, MD
Medizinische Klinik A
Universitätsklinikum Münster
48149 Münster, Germany
Phone +49-251-8352721, Fax +49-251-8352673.
E-mail: Steffen.Koschmieder@ukmuenster.de
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